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Therefore, a pan-coronavirus vaccine that is able to induce immunity targeting combinations of epitopes conserved across the whole coronavirus family should also protect against future variants and emerging viral species, in which these epitopes will likely be retained owing to functional constraints

Numerous microbial species that may produce neurotransmitters, signaling chemicals, or metabolize their precursors into various substances can be found in the human microbiome (163165), during food fermentation and bacterially altered host molecules including bile acids (BAs) (166), tryptophan metabolites, and SCFAs with CNS effects are also produced by the gut bacteria

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Both GH and IGF-1 treatments are also associated with protective and regenerative effects in various brain injury protocols (4448)